Vitamin B13

(orotna kiselina)

Orotna kiselina je heterociklično jedinjenje koje je takođe poznato pod nazivom pirimidin karboksilna kiselina. Ranije se smatrala delom kompleksa vitamina B, ali se danas više ne svrstava u vitamine.

Fizičke i hemijske osobine

Po svojoj strukturi vitamin B13 je 6-uracil karbonska kiselina. U slobodnom stanju to su beli kristali, tačke topljenja od 345 do 346°C.

Vitamin B13 se ne rastvara u kiselinama. Dobro se rastvara u bazama i u vreloj vodi.

Orotna kiselina

Biološka uloga

Vitamin B13 se stvara u tankom crevu čoveka.

Biološka uloga vitamina B13 – orotne kiseline je u tome, što je ovaj vitamin važan biosintetski prekursor pirimidinskih nukleotida.

Vitamin B13 pozitivno utiče na razvitak ploda pri trudnoći.

Kod ptica i sisara vitamin B13 se sintetizuje iz asparaginske kiseline i karbamoil fosfata.

Vitamin B13 pojačava rast mikroorganizama i viših životinja.

Prirodni izvori

Vitamin B13 je prvi put izolovana iz surutke kravljeg mleka. Nalazi se u mleku (kobila 324 miligrama, krava 100, majčino mleko 7, mleko svinja 5 miligrama na 100 mililitara mleka, a zatim i u kozjem i ovčjem mleku).

Najveća količina vitamina B13 je nađena u ekstraktu kvasca i jetre.

Poremećaji

Avitaminoza

Nema mnogo podataka koji bi ukazivali na poremećaje koji nastaju usled nedostatka vitamina B13.

Hipervitaminoza

Nema mnogo podataka koji bi ukazivali na poremećaje koji nastaju usled preteranog unosa vitamina B13.

Preporučene dnevne količine

Potreba čoveka u ovom vitaminu je velika i iznosi 1 do 1,5 grama dnevno.

Upotreba u medicini

Kalijumova so orotne kiseline se koristi u medicinskoj praksi pri bolestima vezanim sa narušavanje metabolizma proteina, zatim za normalizaciju funkcije jetre, pri dugoj upotrebi steroidnih hormona, kao i za ubrzanu adaptaciju od hipoksije. Pored toga, vitamin B13 je izraziti anabolik. Osim što pokazuje dejstvo na rast, vitamin B13 se u pojedinim slučajevima primenjuje za lečenje, zajedno sa aminokiselinom metioninom i vitaminima grupe B (vitamin B12, folna kiselina).

U kompleksnom lečenju bolesnika sa infarktom miokarda pokazala se korisna kombinacija vitamina B13 (1,5 grama dnevno), folne kiseline (60 miligrama dnevno) i vitamina B12 (100 mikrograma dnevno).

Kalijum-orotat (so orotne kiseline) se primenjuje pri lečenju bolesti jetre, srca i nekih vrsta anemija.

Ponekad se vitamin B13 koristi kao nosač minerala u pomoćnim lekovitim sredstvima da bi se povećala njihova biousvojivost. Najčešći primer je vezivanje litijuma (litijum orotat).

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